1 Introduction

Input data:

  • File name: ~/share/anastasiaHIVTest/Total dataset Anastasia.csv
  • Filter on diagnosis year applied: [2009, 2018]

Adjustments:

  • Multiple Imputation using Chained Equations - MICE
    • Number of imputations: 2
    • Number of mice iterations: 2
    • Number of degrees of freedom for spline of diagnosis calendar year: 4
    • Impute reporting delays inputs: TRUE
  • Reporting Delays
    • Diagnosis start year: 2000
    • Notification end year: 2017
    • Notification end quarter (integer between 1 and 4): 1
    • Gender: TRUE
    • Transmission: TRUE
    • Migration: TRUE

Report options:

  • Correction of count of cases for reporting delay.
  • Smoothed version of calendar time.
  • CD4 plots without inter-quartile range.

2 Comparison of data by Gender

2.1 Number of diagnoses per year

Data stratified by gender is shown only for unadjusted data since there were no missing data on gender after pre-processing, which takes place before adjustments.

2.1.1 Before and after adjustments

Year of diagnosis Male [N (%)] Female [N (%)] Total [N (%)]
1985 16 (100) - (-) 16 (100)
1986 13 (65) 7 (35) 20 (100)
1987 58 (75) 19 (25) 77 (100)
1988 50 (79) 13 (21) 63 (100)
1989 41 (72) 16 (28) 57 (100)
1990 158 (80) 39 (20) 197 (100)
1991 325 (80) 79 (20) 404 (100)
1992 239 (79) 64 (21) 303 (100)
1993 57 (75) 19 (25) 76 (100)
1994 65 (71) 26 (29) 91 (100)
1995 69 (73) 25 (27) 94 (100)
1996 856 (74) 294 (26) 1150 (100)
1997 849 (75) 287 (25) 1136 (100)
1998 773 (74) 278 (26) 1051 (100)
1999 462 (69) 212 (31) 674 (100)
2000 614 (72) 243 (28) 857 (100)
2001 771 (74) 266 (26) 1037 (100)
2002 931 (70) 406 (30) 1337 (100)
2003 978 (62) 603 (38) 1581 (100)
2004 1044 (60) 685 (40) 1729 (100)
2005 1192 (60) 779 (40) 1971 (100)
2006 1329 (63) 795 (37) 2124 (100)
2007 997 (65) 543 (35) 1540 (100)
2008 1251 (64) 702 (36) 1953 (100)
2009 22553 (70) 9719 (30) 32272 (100)
2010 22353 (70) 9480 (30) 31833 (100)
2011 23183 (71) 9378 (29) 32561 (100)
2012 24448 (72) 9653 (28) 34101 (100)
2013 24555 (72) 9419 (28) 33974 (100)
2014 25685 (72) 10052 (28) 35737 (100)
2015 27110 (73) 10059 (27) 37169 (100)
2016 34400 (69) 15618 (31) 50018 (100)
2017 35276 (69) 16134 (31) 51410 (100)
2018 34118 (68) 15751 (32) 49869 (100)
Total 286819 (70) 121663 (30) 408482 (100)

2.2 Median CD4 cell count (cells/µL)

2.2.1 Before adjustments

Year of diagnosis Male [Median (IQR)] Female [Median (IQR)] Overall [Median (IQR)]
1985 - (-, -) - (-, -) - (-, -)
1986 - (-, -) - (-, -) - (-, -)
1987 461 (461, 461) - (-, -) 461 (461, 461)
1988 224 (164, 520) - (-, -) 224 (164, 520)
1989 333 (221, 460) 471 (471, 471) 414 (252, 471)
1990 143 (96, 264) 245 (245, 245) 156 (108, 273)
1991 154 (84, 362) 200 (200, 200) 177 (91, 349)
1992 148 (103, 240) 86 (86, 86) 144 (86, 223)
1993 240 (84, 660) 295 (170, 466) 240 (137, 582)
1994 275 (142, 390) 490 (280, 815) 294 (138, 474)
1995 440 (237, 586) 504 (504, 504) 440 (244, 564)
1996 561 (335, 634) 453 (350, 511) 548 (299, 594)
1997 530 (298, 807) 171 (140, 201) 285 (239, 640)
1998 224 (146, 470) 396 (266, 526) 224 (141, 505)
1999 321 (187, 415) 219 (173, 381) 240 (180, 415)
2000 315 (130, 511) 395 (61, 412) 332 (101, 466)
2001 246 (88, 390) 356 (250, 498) 258 (97, 399)
2002 345 (188, 514) 315 (148, 406) 342 (176, 453)
2003 250 (201, 395) 269 (165, 387) 260 (172, 393)
2004 258 (146, 350) 408 (217, 481) 285 (160, 448)
2005 293 (162, 451) 216 (94, 498) 284 (134, 462)
2006 308 (152, 418) 265 (125, 371) 298 (149, 411)
2007 286 (154, 433) 349 (261, 496) 307 (169, 439)
2008 305 (186, 423) 313 (178, 487) 306 (182, 432)
2009 360 (178, 543) 334 (160, 531) 352 (170, 540)
2010 363 (179, 550) 331 (160, 525) 353 (172, 543)
2011 366 (177, 550) 341 (166, 533) 360 (174, 545)
2012 366 (178, 553) 338 (163, 532) 358 (173, 549)
2013 381 (189, 570) 353 (180, 554) 373 (187, 565)
2014 382 (190, 574) 350 (174, 549) 373 (186, 568)
2015 382 (193, 571) 358 (177, 554) 375 (189, 568)
2016 348 (170, 530) 337 (168, 526) 344 (170, 528)
2017 336 (154, 522) 324 (150, 511) 331 (153, 519)
2018 331 (152, 520) 325 (147, 510) 330 (150, 517)
Overall 359 (173, 546) 338 (162, 529) 351 (170, 541)

2.2.2 After adjustments

Year of diagnosis Male [Median (IQR)] Female [Median (IQR)]
1985 388 (210, 579) - (-, -)
1986 383 (207, 574) 458 (278, 631)
1987 379 (204, 568) 450 (271, 624)
1988 375 (202, 563) 441 (263, 616)
1989 371 (199, 558) 433 (256, 609)
1990 367 (196, 553) 425 (249, 603)
1991 363 (193, 549) 417 (243, 596)
1992 360 (191, 544) 410 (236, 589)
1993 356 (188, 540) 402 (230, 583)
1994 353 (186, 537) 395 (224, 577)
1995 350 (184, 533) 389 (218, 572)
1996 348 (182, 530) 382 (213, 567)
1997 346 (181, 527) 377 (208, 562)
1998 344 (179, 525) 371 (203, 557)
1999 343 (178, 524) 366 (199, 553)
2000 342 (177, 522) 362 (195, 549)
2001 341 (176, 522) 358 (191, 546)
2002 341 (176, 522) 354 (188, 543)
2003 342 (176, 522) 351 (186, 541)
2004 343 (176, 524) 349 (183, 539)
2005 345 (177, 525) 347 (181, 538)
2006 347 (178, 528) 346 (180, 538)
2007 350 (179, 532) 345 (179, 538)
2008 353 (180, 536) 346 (178, 538)
2009 358 (182, 541) 346 (178, 540)
2010 363 (185, 547) 348 (179, 542)
2011 369 (188, 554) 350 (180, 545)
2012 375 (191, 562) 353 (181, 548)
2013 380 (195, 567) 356 (183, 551)
2014 382 (198, 569) 358 (185, 552)
2015 378 (199, 563) 358 (187, 549)
2016 370 (195, 553) 353 (182, 543)
2017 358 (182, 543) 342 (169, 531)
2018 344 (165, 531) 328 (150, 517)

3 Comparison of data by Transmission

3.1 Number of diagnoses per year

3.1.1 Before adjustments

Year of diagnosis Hetero [N (%)] IDU [N (%)] MSM [N (%)] MTCT [N (%)] Nosocomial [N (%)] Transfusion [N (%)] Missing [N (%)] Overall [N (%)]
1985 - (-) 2 (12) 5 (31) - (-) - (-) 9 (56) - (-) 16 (100)
1986 9 (45) 4 (20) 3 (15) - (-) - (-) 3 (15) 1 (5) 20 (100)
1987 39 (51) 6 (8) 16 (21) 1 (1) - (-) 8 (10) 7 (9) 77 (100)
1988 29 (46) 3 (5) 24 (38) - (-) - (-) 2 (3) 5 (8) 63 (100)
1989 27 (47) 4 (7) 18 (32) 4 (7) - (-) - (-) 4 (7) 57 (100)
1990 57 (29) 17 (9) 108 (55) 1 (1) - (-) 5 (3) 9 (5) 197 (100)
1991 140 (35) 37 (9) 188 (47) 5 (1) 1 (0) 5 (1) 28 (7) 404 (100)
1992 103 (34) 37 (12) 124 (41) 6 (2) - (-) 3 (1) 30 (10) 303 (100)
1993 32 (42) 6 (8) 32 (42) - (-) - (-) 1 (1) 5 (7) 76 (100)
1994 47 (52) - (-) 34 (37) 3 (3) - (-) 2 (2) 5 (5) 91 (100)
1995 53 (56) 2 (2) 28 (30) - (-) - (-) 1 (1) 10 (11) 94 (100)
1996 126 (11) 980 (85) 27 (2) 5 (0) - (-) 1 (0) 11 (1) 1150 (100)
1997 164 (14) 894 (79) 16 (1) 6 (1) - (-) 1 (0) 55 (5) 1136 (100)
1998 208 (20) 788 (75) 20 (2) 2 (0) - (-) - (-) 33 (3) 1051 (100)
1999 189 (28) 450 (67) 15 (2) 3 (0) - (-) 2 (0) 15 (2) 674 (100)
2000 217 (25) 590 (69) 23 (3) 8 (1) - (-) - (-) 19 (2) 857 (100)
2001 268 (26) 678 (65) 19 (2) 4 (0) - (-) - (-) 68 (7) 1037 (100)
2002 459 (34) 786 (59) 32 (2) 5 (0) - (-) 1 (0) 54 (4) 1337 (100)
2003 657 (42) 691 (44) 104 (7) 17 (1) - (-) 4 (0) 108 (7) 1581 (100)
2004 815 (47) 668 (39) 100 (6) 30 (2) 1 (0) 2 (0) 113 (7) 1729 (100)
2005 1030 (52) 699 (35) 102 (5) 54 (3) 1 (0) 9 (0) 76 (4) 1971 (100)
2006 1134 (53) 733 (35) 133 (6) 47 (2) - (-) 3 (0) 74 (3) 2124 (100)
2007 800 (52) 622 (40) 40 (3) 28 (2) - (-) 1 (0) 49 (3) 1540 (100)
2008 1080 (55) 519 (27) 173 (9) 37 (2) - (-) 1 (0) 143 (7) 1953 (100)
2009 13373 (41) 3903 (12) 9612 (30) 381 (1) 55 (0) 80 (0) 4868 (15) 32272 (100)
2010 13226 (42) 3537 (11) 10045 (32) 427 (1) 28 (0) 93 (0) 4477 (14) 31833 (100)
2011 13275 (41) 3792 (12) 10159 (31) 387 (1) 68 (0) 78 (0) 4802 (15) 32561 (100)
2012 13691 (40) 3717 (11) 11041 (32) 405 (1) 104 (0) 88 (0) 5055 (15) 34101 (100)
2013 13353 (39) 3125 (9) 11279 (33) 366 (1) 26 (0) 89 (0) 5736 (17) 33974 (100)
2014 14537 (41) 3081 (9) 11661 (33) 391 (1) 42 (0) 93 (0) 5932 (17) 35737 (100)
2015 14472 (39) 3594 (10) 11852 (32) 376 (1) 28 (0) 77 (0) 6770 (18) 37169 (100)
2016 24083 (48) 6749 (13) 11364 (23) 331 (1) 38 (0) 90 (0) 7363 (15) 50018 (100)
2017 25498 (50) 6942 (14) 10841 (21) 352 (1) 33 (0) 73 (0) 7671 (15) 51410 (100)
2018 25630 (51) 6302 (13) 9995 (20) 345 (1) 19 (0) 80 (0) 7498 (15) 49869 (100)
Overall 178821 (44) 53958 (13) 109233 (27) 4027 (1) 444 (0) 905 (0) 61094 (15) 408482 (100)

3.1.2 After adjustments

Year of diagnosis Hetero [N (%)] IDU [N (%)] MSM [N (%)] MTCT [N (%)] Nosocomial [N (%)] Transfusion [N (%)] Overall [N (%)]
1985 - (-) 2 (12) 5 (31) - (-) - (-) 9 (56) 16 (100)
1986 9 (45) 4 (20) 4 (20) - (-) - (-) 3 (15) 20 (100)
1987 39 (51) 12 (16) 17 (22) 1 (1) - (-) 8 (10) 77 (100)
1988 31 (49) 6 (10) 24 (38) - (-) - (-) 2 (3) 63 (100)
1989 27 (47) 7 (12) 19 (33) 4 (7) - (-) - (-) 57 (100)
1990 60 (30) 18 (9) 112 (57) 2 (1) - (-) 5 (3) 197 (100)
1991 147 (36) 51 (13) 194 (48) 5 (1) 1 (0) 6 (1) 404 (100)
1992 113 (37) 55 (18) 126 (42) 6 (2) - (-) 3 (1) 303 (100)
1993 35 (46) 8 (11) 32 (42) - (-) - (-) 1 (1) 76 (100)
1994 48 (53) 4 (4) 34 (37) 3 (3) - (-) 2 (2) 91 (100)
1995 56 (60) 8 (9) 29 (31) - (-) - (-) 1 (1) 94 (100)
1996 129 (11) 986 (86) 29 (3) 5 (0) - (-) 1 (0) 1150 (100)
1997 181 (16) 929 (82) 19 (2) 6 (1) - (-) 1 (0) 1136 (100)
1998 217 (21) 809 (77) 23 (2) 2 (0) - (-) - (-) 1051 (100)
1999 192 (28) 461 (68) 16 (2) 3 (0) - (-) 2 (0) 674 (100)
2000 227 (26) 597 (70) 24 (3) 9 (1) - (-) - (-) 857 (100)
2001 288 (28) 717 (69) 28 (3) 4 (0) - (-) - (-) 1037 (100)
2002 480 (36) 810 (61) 41 (3) 5 (0) - (-) 1 (0) 1337 (100)
2003 702 (44) 739 (47) 118 (7) 18 (1) - (-) 4 (0) 1581 (100)
2004 872 (50) 706 (41) 116 (7) 32 (2) 1 (0) 2 (0) 1729 (100)
2005 1063 (54) 722 (37) 121 (6) 55 (3) 1 (0) 9 (0) 1971 (100)
2006 1171 (55) 750 (35) 152 (7) 47 (2) - (-) 4 (0) 2124 (100)
2007 820 (53) 646 (42) 48 (3) 28 (2) - (-) 1 (0) 1544 (100)
2008 1143 (58) 565 (29) 213 (11) 38 (2) - (-) 1 (0) 1960 (100)
2009 15837 (49) 4922 (15) 11204 (34) 437 (1) 62 (0) 93 (0) 32556 (100)
2010 15699 (48) 4273 (13) 11793 (36) 469 (1) 40 (0) 103 (0) 32378 (100)
2011 15879 (48) 4501 (14) 12293 (37) 439 (1) 74 (0) 91 (0) 33276 (100)
2012 16394 (47) 4293 (12) 13596 (39) 457 (1) 109 (0) 108 (0) 34957 (100)
2013 16495 (47) 3713 (11) 14216 (41) 417 (1) 38 (0) 108 (0) 34987 (100)
2014 17998 (49) 3710 (10) 14701 (40) 457 (1) 47 (0) 115 (0) 37028 (100)
2015 18657 (48) 4560 (12) 15046 (39) 444 (1) 34 (0) 96 (0) 38837 (100)
2016 30480 (56) 8367 (15) 14995 (28) 427 (1) 46 (0) 113 (0) 54428 (100)
2017 32848 (58) 8627 (15) 14536 (26) 481 (1) 39 (0) 93 (0) 56623 (100)
2018 29979 (60) 7331 (15) 11996 (24) 445 (1) 27 (0) 91 (0) 49869 (100)
Overall 218316 (51) 63911 (15) 135922 (32) 4746 (1) 519 (0) 1078 (0) 424491 (100)

3.2 Median CD4 cell count (cells/µL)

3.2.1 Before adjustments

Year of diagnosis Hetero [Median (IQR)] IDU [Median (IQR)] MSM [Median (IQR)] MTCT [Median (IQR)] Nosocomial [Median (IQR)] Transfusion [Median (IQR)] Missing [Median (IQR)] Overall [Median (IQR)]
1985 - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -)
1986 - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -)
1987 461 (461, 461) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) - (-, -) 461 (461, 461)
1988 - (-, -) - (-, -) 224 (164, 520) - (-, -) - (-, -) - (-, -) - (-, -) 224 (164, 520)
1989 471 (471, 471) - (-, -) 333 (221, 460) - (-, -) - (-, -) - (-, -) - (-, -) 414 (252, 471)
1990 - (-, -) 245 (245, 245) 130 (85, 156) - (-, -) - (-, -) - (-, -) 300 (300, 300) 156 (108, 273)
1991 200 (200, 200) - (-, -) 154 (84, 362) - (-, -) - (-, -) - (-, -) - (-, -) 177 (91, 349)
1992 99 (92, 106) - (-, -) 151 (110, 258) - (-, -) - (-, -) - (-, -) - (-, -) 144 (86, 223)
1993 514 (234, 727) - (-, -) 170 (39, 397) - (-, -) - (-, -) 112 (112, 112) 240 (240, 240) 240 (137, 582)
1994 331 (267, 466) - (-, -) 146 (82, 390) - (-, -) - (-, -) - (-, -) - (-, -) 294 (138, 474)
1995 472 (351, 561) - (-, -) 366 (244, 564) - (-, -) - (-, -) - (-, -) - (-, -) 440 (244, 564)
1996 565 (402, 617) - (-, -) 512 (258, 567) - (-, -) - (-, -) - (-, -) - (-, -) 548 (299, 594)
1997 271 (201, 420) - (-, -) 619 (439, 798) - (-, -) - (-, -) - (-, -) - (-, -) 285 (239, 640)
1998 190 (152, 331) 155 (63, 225) 502 (212, 564) - (-, -) - (-, -) - (-, -) - (-, -) 224 (141, 505)
1999 212 (198, 324) 350 (172, 478) 391 (201, 410) - (-, -) - (-, -) 150 (150, 150) - (-, -) 240 (180, 415)
2000 129 (59, 413) 332 (155, 526) 313 (225, 402) - (-, -) - (-, -) - (-, -) 427 (427, 427) 332 (101, 466)
2001 298 (153, 530) 133 (81, 284) 262 (262, 262) - (-, -) - (-, -) - (-, -) 472 (434, 812) 258 (97, 399)
2002 252 (142, 354) 346 (148, 564) 363 (231, 535) - (-, -) - (-, -) - (-, -) 408 (387, 467) 342 (176, 453)
2003 225 (127, 311) 250 (196, 380) - (-, -) - (-, -) - (-, -) - (-, -) 540 (476, 581) 260 (172, 393)
2004 291 (144, 467) 262 (186, 338) 382 (327, 449) 682 (682, 682) - (-, -) 48 (48, 48) - (-, -) 285 (160, 448)
2005 268 (123, 477) 284 (153, 442) - (-, -) 457 (236, 807) - (-, -) 1686 (1686, 1686) 480 (480, 480) 284 (134, 462)
2006 283 (129, 368) 314 (160, 428) 151 (151, 151) - (-, -) - (-, -) - (-, -) 165 (92, 239) 298 (149, 411)
2007 298 (179, 431) 319 (156, 441) - (-, -) 500 (436, 565) - (-, -) - (-, -) 318 (230, 468) 307 (169, 439)
2008 254 (142, 388) 319 (211, 433) 217 (36, 402) 613 (596, 1141) - (-, -) - (-, -) 216 (148, 255) 306 (182, 432)
2009 304 (131, 496) 371 (212, 558) 413 (246, 584) 550 (252, 953) 246 (111, 481) 338 (145, 453) 243 (62, 437) 352 (170, 540)
2010 300 (130, 488) 375 (191, 543) 416 (250, 596) 620 (333, 1110) 181 (120, 320) 315 (182, 537) 229 (61, 450) 353 (172, 543)
2011 305 (130, 489) 371 (185, 568) 419 (252, 599) 552 (287, 1010) 322 (258, 470) 341 (161, 568) 244 (67, 456) 360 (174, 545)
2012 310 (130, 499) 318 (158, 522) 427 (260, 600) 590 (307, 1168) 422 (248, 547) 361 (247, 507) 224 (62, 424) 358 (173, 549)
2013 320 (145, 512) 331 (147, 538) 443 (270, 619) 619 (341, 1205) 493 (460, 667) 302 (146, 498) 272 (84, 473) 373 (187, 565)
2014 325 (146, 518) 316 (137, 502) 445 (276, 625) 572 (294, 1122) 325 (77, 677) 370 (176, 590) 252 (84, 490) 373 (186, 568)
2015 325 (149, 519) 339 (148, 535) 440 (271, 628) 681 (331, 1194) 364 (232, 574) 359 (200, 528) 303 (108, 519) 375 (189, 568)
2016 313 (144, 501) 318 (155, 501) 430 (263, 602) 590 (277, 1086) 279 (80, 621) 327 (200, 571) 298 (100, 506) 344 (170, 528)
2017 298 (128, 489) 320 (148, 503) 423 (253, 605) 588 (228, 1263) 310 (120, 540) 277 (123, 482) 288 (97, 501) 331 (153, 519)
2018 299 (123, 494) 332 (161, 505) 408 (244, 590) 530 (207, 1080) 328 (161, 508) 268 (123, 500) 303 (113, 505) 330 (150, 517)
Overall 309 (135, 500) 334 (161, 517) 428 (260, 606) 592 (278, 1130) 323 (147, 578) 326 (168, 528) 270 (84, 484) 351 (170, 541)

3.2.2 After adjustments

Year of diagnosis Hetero [Median (IQR)] IDU [Median (IQR)] MSM [Median (IQR)] MTCT [Median (IQR)] Nosocomial [Median (IQR)] Transfusion [Median (IQR)]
1985 - (-, -) 383 (230, 574) 323 (107, 524) - (-, -) - (-, -) 327 (124, 572)
1986 360 (176, 560) 383 (230, 572) 325 (112, 525) - (-, -) - (-, -) 327 (126, 568)
1987 356 (173, 555) 383 (230, 570) 328 (116, 526) 434 (287, 771) - (-, -) 327 (127, 563)
1988 352 (171, 550) 383 (230, 568) 330 (121, 527) - (-, -) - (-, -) 326 (129, 559)
1989 348 (168, 545) 383 (230, 566) 332 (127, 528) 436 (274, 762) - (-, -) - (-, -)
1990 344 (166, 540) 382 (230, 564) 335 (132, 529) 438 (267, 758) - (-, -) 325 (132, 550)
1991 341 (164, 535) 382 (230, 562) 337 (137, 530) 439 (261, 755) 380 (380, 380) 325 (134, 545)
1992 337 (161, 531) 382 (230, 560) 340 (142, 531) 440 (256, 753) - (-, -) 325 (135, 541)
1993 334 (159, 526) 381 (229, 558) 343 (148, 533) - (-, -) - (-, -) 324 (137, 537)
1994 330 (157, 522) 381 (229, 556) 345 (153, 534) 444 (246, 750) - (-, -) 324 (138, 534)
1995 327 (155, 518) 380 (228, 554) 348 (159, 536) - (-, -) - (-, -) 324 (140, 530)
1996 324 (153, 514) 379 (227, 553) 351 (165, 538) 450 (239, 753) - (-, -) 323 (141, 527)
1997 322 (151, 511) 379 (226, 551) 354 (170, 540) 453 (236, 755) - (-, -) 323 (143, 523)
1998 319 (150, 508) 378 (224, 549) 357 (176, 542) 456 (234, 760) - (-, -) - (-, -)
1999 317 (148, 505) 377 (223, 548) 361 (182, 545) 460 (232, 766) - (-, -) 323 (146, 518)
2000 315 (147, 502) 376 (221, 547) 364 (188, 547) 465 (232, 773) - (-, -) - (-, -)
2001 313 (145, 500) 374 (219, 545) 368 (194, 550) 470 (232, 783) - (-, -) - (-, -)
2002 312 (144, 499) 373 (216, 544) 372 (199, 553) 476 (233, 794) - (-, -) 322 (150, 511)
2003 311 (143, 497) 371 (213, 543) 376 (205, 557) 482 (235, 808) - (-, -) 322 (151, 510)
2004 310 (142, 496) 369 (210, 542) 381 (211, 561) 490 (239, 824) 274 (235, 460) 322 (153, 509)
2005 310 (142, 496) 367 (207, 541) 385 (217, 565) 497 (243, 843) 279 (229, 472) 322 (154, 508)
2006 310 (141, 496) 365 (203, 541) 390 (223, 569) 506 (248, 864) - (-, -) 322 (155, 508)
2007 310 (141, 497) 363 (199, 540) 395 (229, 574) 516 (255, 888) - (-, -) 323 (156, 507)
2008 311 (141, 498) 360 (194, 540) 401 (235, 579) 526 (263, 916) - (-, -) 323 (158, 508)
2009 312 (141, 499) 357 (190, 539) 406 (240, 585) 538 (273, 947) 327 (212, 530) 323 (159, 509)
2010 314 (141, 502) 355 (184, 539) 413 (246, 591) 550 (284, 982) 347 (210, 549) 323 (160, 510)
2011 316 (142, 505) 351 (179, 539) 419 (252, 598) 564 (297, 1021) 372 (209, 568) 324 (161, 512)
2012 318 (143, 508) 348 (173, 540) 426 (258, 605) 579 (311, 1065) 398 (206, 589) 325 (162, 515)
2013 322 (145, 511) 345 (169, 539) 432 (263, 611) 600 (325, 1118) 409 (192, 603) 329 (166, 522)
2014 326 (150, 514) 343 (167, 537) 436 (268, 615) 629 (335, 1185) 385 (156, 602) 339 (176, 539)
2015 330 (157, 516) 343 (169, 532) 438 (271, 616) 665 (337, 1260) 326 (105, 582) 354 (191, 563)
2016 328 (159, 513) 343 (171, 526) 435 (271, 613) 671 (321, 1280) 280 (79, 555) 356 (196, 571)
2017 318 (147, 506) 341 (168, 521) 428 (265, 606) 618 (282, 1193) 287 (101, 530) 330 (176, 541)
2018 302 (128, 496) 338 (164, 515) 417 (255, 596) 534 (233, 1049) 327 (163, 508) 289 (143, 490)

4 Comparison of data by Migration

4.1 Number of diagnoses per year

4.1.1 Before adjustments

Year of diagnosis OTHER [N (%)] REPCOUNTRY [N (%)] Missing [N (%)] Overall [N (%)]
1985 - (-) 16 (100) - (-) 16 (100)
1986 5 (25) 15 (75) - (-) 20 (100)
1987 30 (39) 47 (61) - (-) 77 (100)
1988 19 (30) 40 (63) 4 (6) 63 (100)
1989 15 (26) 40 (70) 2 (4) 57 (100)
1990 41 (21) 147 (75) 9 (5) 197 (100)
1991 75 (19) 326 (81) 3 (1) 404 (100)
1992 66 (22) 236 (78) 1 (0) 303 (100)
1993 16 (21) 57 (75) 3 (4) 76 (100)
1994 11 (12) 71 (78) 9 (10) 91 (100)
1995 19 (20) 67 (71) 8 (9) 94 (100)
1996 31 (3) 1116 (97) 3 (0) 1150 (100)
1997 28 (2) 1108 (98) - (-) 1136 (100)
1998 36 (3) 1012 (96) 3 (0) 1051 (100)
1999 20 (3) 642 (95) 12 (2) 674 (100)
2000 19 (2) 808 (94) 30 (4) 857 (100)
2001 21 (2) 958 (92) 58 (6) 1037 (100)
2002 18 (1) 1277 (96) 42 (3) 1337 (100)
2003 232 (15) 1267 (80) 82 (5) 1581 (100)
2004 193 (11) 1454 (84) 82 (5) 1729 (100)
2005 190 (10) 1742 (88) 39 (2) 1971 (100)
2006 187 (9) 1887 (89) 50 (2) 2124 (100)
2007 10 (1) 1517 (99) 13 (1) 1540 (100)
2008 218 (11) 1657 (85) 78 (4) 1953 (100)
2009 10318 (32) 18241 (57) 3713 (12) 32272 (100)
2010 10429 (33) 17682 (56) 3722 (12) 31833 (100)
2011 10161 (31) 18718 (57) 3682 (11) 32561 (100)
2012 10521 (31) 19999 (59) 3581 (11) 34101 (100)
2013 9880 (29) 20616 (61) 3478 (10) 33974 (100)
2014 10367 (29) 20368 (57) 5002 (14) 35737 (100)
2015 10663 (29) 22524 (61) 3982 (11) 37169 (100)
2016 9943 (20) 35934 (72) 4141 (8) 50018 (100)
2017 9679 (19) 37464 (73) 4267 (8) 51410 (100)
2018 9725 (20) 36256 (73) 3888 (8) 49869 (100)
Overall 103186 (25) 265309 (65) 39987 (10) 408482 (100)

4.1.2 After adjustments

Year of diagnosis OTHER [N (%)] REPCOUNTRY [N (%)] Overall [N (%)]
1985 - (-) 16 (100) 16 (100)
1986 5 (25) 15 (75) 20 (100)
1987 30 (39) 47 (61) 77 (100)
1988 19 (30) 44 (70) 63 (100)
1989 15 (26) 42 (74) 57 (100)
1990 42 (21) 155 (79) 197 (100)
1991 75 (19) 329 (81) 404 (100)
1992 66 (22) 237 (78) 303 (100)
1993 16 (21) 60 (79) 76 (100)
1994 11 (12) 80 (88) 91 (100)
1995 19 (20) 75 (80) 94 (100)
1996 32 (3) 1118 (97) 1150 (100)
1997 28 (2) 1108 (98) 1136 (100)
1998 36 (3) 1015 (97) 1051 (100)
1999 20 (3) 654 (97) 674 (100)
2000 21 (2) 836 (98) 857 (100)
2001 28 (3) 1009 (97) 1037 (100)
2002 22 (2) 1315 (98) 1337 (100)
2003 247 (16) 1334 (84) 1581 (100)
2004 210 (12) 1519 (88) 1729 (100)
2005 197 (10) 1774 (90) 1971 (100)
2006 200 (9) 1924 (91) 2124 (100)
2007 11 (1) 1533 (99) 1544 (100)
2008 245 (13) 1715 (87) 1960 (100)
2009 11554 (35) 21002 (65) 32556 (100)
2010 11848 (37) 20530 (63) 32378 (100)
2011 11613 (35) 21663 (65) 33276 (100)
2012 12046 (34) 22911 (66) 34957 (100)
2013 11461 (33) 23526 (67) 34987 (100)
2014 12489 (34) 24539 (66) 37028 (100)
2015 12285 (32) 26552 (68) 38837 (100)
2016 11769 (22) 42659 (78) 54428 (100)
2017 11752 (21) 44871 (79) 56623 (100)
2018 10620 (21) 39249 (79) 49869 (100)
Overall 119033 (28) 305457 (72) 424491 (100)

4.2 Median CD4 cell count (cells/µL)

4.2.1 Before adjustments

Year of diagnosis OTHER [Median (IQR)] REPCOUNTRY [Median (IQR)] Missing [Median (IQR)] Overall [Median (IQR)]
1985 - (-, -) - (-, -) - (-, -) - (-, -)
1986 - (-, -) - (-, -) - (-, -) - (-, -)
1987 - (-, -) 461 (461, 461) - (-, -) 461 (461, 461)
1988 - (-, -) 224 (164, 520) - (-, -) 224 (164, 520)
1989 - (-, -) 414 (252, 471) - (-, -) 414 (252, 471)
1990 245 (245, 245) 143 (96, 264) - (-, -) 156 (108, 273)
1991 200 (200, 200) 154 (84, 362) - (-, -) 177 (91, 349)
1992 70 (63, 78) 151 (128, 258) - (-, -) 144 (86, 223)
1993 - (-, -) 173 (112, 417) 771 (662, 880) 240 (137, 582)
1994 - (-, -) 275 (127, 466) 368 (249, 446) 294 (138, 474)
1995 398 (345, 451) 440 (230, 608) - (-, -) 440 (244, 564)
1996 732 (592, 871) 548 (231, 583) - (-, -) 548 (299, 594)
1997 - (-, -) 285 (239, 640) - (-, -) 285 (239, 640)
1998 - (-, -) 224 (141, 505) - (-, -) 224 (141, 505)
1999 430 (220, 660) 212 (180, 379) 667 (667, 667) 240 (180, 415)
2000 349 (324, 374) 161 (77, 383) 564 (513, 765) 332 (101, 466)
2001 702 (585, 833) 168 (83, 310) 417 (400, 566) 258 (97, 399)
2002 413 (218, 648) 257 (116, 353) 582 (400, 638) 342 (176, 453)
2003 318 (178, 459) 236 (165, 324) 520 (392, 574) 260 (172, 393)
2004 331 (331, 331) 291 (160, 456) 125 (72, 179) 285 (160, 448)
2005 204 (204, 204) 286 (132, 462) - (-, -) 284 (134, 462)
2006 - (-, -) 298 (149, 411) - (-, -) 298 (149, 411)
2007 530 (530, 530) 307 (169, 438) 379 (379, 379) 307 (169, 439)
2008 113 (30, 280) 310 (185, 432) - (-, -) 306 (182, 432)
2009 306 (140, 496) 381 (198, 566) 389 (182, 600) 352 (170, 540)
2010 318 (144, 503) 388 (201, 570) 308 (140, 492) 353 (172, 543)
2011 320 (146, 504) 384 (196, 573) 342 (154, 513) 360 (174, 545)
2012 320 (148, 509) 384 (196, 570) 352 (155, 548) 358 (173, 549)
2013 345 (170, 535) 390 (199, 582) 375 (182, 540) 373 (187, 565)
2014 354 (171, 550) 385 (195, 577) 377 (190, 569) 373 (186, 568)
2015 370 (180, 563) 377 (195, 569) 392 (191, 610) 375 (189, 568)
2016 369 (180, 562) 337 (167, 519) 375 (186, 573) 344 (170, 528)
2017 364 (182, 565) 322 (145, 508) 388 (216, 600) 331 (153, 519)
2018 357 (177, 553) 323 (143, 508) 383 (185, 593) 330 (150, 517)
Overall 340 (162, 536) 356 (173, 543) 366 (177, 560) 351 (170, 541)

4.2.2 After adjustments

Year of diagnosis OTHER [Median (IQR)] REPCOUNTRY [Median (IQR)]
1985 - (-, -) 396 (214, 575)
1986 329 (161, 502) 392 (212, 571)
1987 325 (158, 499) 388 (210, 567)
1988 322 (154, 496) 385 (209, 564)
1989 318 (151, 494) 381 (207, 560)
1990 315 (149, 491) 378 (205, 557)
1991 312 (146, 489) 374 (203, 554)
1992 309 (143, 487) 371 (202, 551)
1993 306 (141, 485) 368 (200, 548)
1994 304 (139, 483) 366 (199, 546)
1995 301 (137, 481) 363 (197, 543)
1996 300 (135, 480) 361 (196, 541)
1997 298 (134, 479) 360 (195, 540)
1998 297 (133, 479) 358 (194, 539)
1999 296 (132, 479) 357 (193, 538)
2000 296 (132, 479) 356 (193, 537)
2001 296 (132, 480) 356 (192, 537)
2002 297 (132, 481) 356 (192, 538)
2003 298 (133, 483) 356 (192, 538)
2004 300 (134, 485) 357 (192, 540)
2005 302 (136, 488) 359 (193, 542)
2006 305 (138, 492) 361 (193, 544)
2007 309 (141, 496) 364 (194, 548)
2008 313 (145, 500) 367 (195, 552)
2009 318 (149, 506) 371 (197, 556)
2010 324 (153, 512) 375 (198, 561)
2011 331 (159, 519) 381 (201, 567)
2012 339 (165, 527) 386 (203, 574)
2013 348 (172, 537) 389 (204, 577)
2014 358 (181, 549) 386 (203, 573)
2015 370 (191, 562) 375 (199, 560)
2016 375 (196, 569) 361 (189, 545)
2017 370 (192, 564) 348 (173, 531)
2018 357 (183, 551) 336 (153, 520)

5 Comparison of the reported and estimated number of diagnoses per year

Diagnosis
year
Reported
 
Weight
estimated
Weight
not estimated
Estimated
unreported
[N (95% CI)]
Estimated
total
[N (95% CI)]
1985 16 0 16 0 (0, 0) 16 (16, 16)
1986 20 0 20 0 (0, 0) 20 (20, 20)
1987 77 0 77 0 (0, 0) 77 (77, 77)
1988 63 0 63 0 (0, 0) 63 (63, 63)
1989 57 0 57 0 (0, 0) 57 (57, 57)
1990 197 0 197 0 (0, 0) 197 (197, 197)
1991 404 0 404 0 (0, 0) 404 (404, 404)
1992 303 0 303 0 (0, 0) 303 (303, 303)
1993 76 0 76 0 (0, 0) 76 (76, 76)
1994 91 0 91 0 (0, 0) 91 (91, 91)
1995 94 0 94 0 (0, 0) 94 (94, 94)
1996 1150 0 1150 0 (0, 0) 1150 (1150, 1150)
1997 1136 0 1136 0 (0, 0) 1136 (1136, 1136)
1998 1051 0 1051 0 (0, 0) 1051 (1051, 1051)
1999 674 0 674 0 (0, 0) 674 (674, 674)
2000 857 0 857 0 (0, 0) 857 (857, 857)
2001 1037 0 1037 0 (0, 0) 1037 (1037, 1037)
2002 1337 0 1337 0 (0, 0) 1337 (1337, 1337)
2003 1581 0 1581 0 (0, 0) 1581 (1581, 1581)
2004 1736 13 1722 0 (-23, 23) 1736 (1713, 1758)
2005 1982 21 1960 0 (-36, 37) 1982 (1945, 2018)
2006 2124 16 2108 0 (-28, 28) 2124 (2096, 2152)
2007 1540 310 1230 2 (-72, 76) 1542 (1468, 1616)
2008 1953 784 1168 5 (-65, 75) 1958 (1888, 2028)
2009 32272 17364 14908 187 (-10718, 11091) 32459 (21554, 43363)
2010 31833 28496 3336 368 (-5970, 6707) 32201 (25863, 38540)
2011 32561 30500 2060 488 (-301, 1278) 33049 (32260, 33839)
2012 34101 32183 1918 613 (-245, 1470) 34714 (33856, 35571)
2013 33974 31557 2417 766 (-119, 1652) 34740 (33855, 35626)
2014 35737 34696 1042 1024 (93, 1955) 36761 (35830, 37692)
2015 37169 36132 1038 1387 (410, 2365) 38556 (37579, 39534)
2016 50018 49172 846 4046 (2750, 5343) 54064 (52768, 55361)
2017 51410 13050 38360 5101 (4672, 5531) 56511 (56082, 56941)
2018 49869 0 49869 0 (0, 0) 49869 (49869, 49869)
Total 408499 274296 134204 13989 (-9651, 37629) 422488 (398848, 446128)